Endocrine Abstracts

Prokineticins (Prok1 and Prok2) are chemokine-like peptides, which regulate through two G-protein-coupled receptors, ProkR1 and ProkR2, different physiological and pathological functions. Prok1 plays a significant role in tumour development and progression in several tissues. There are few data on the involvement of Prok1 and ProkR1 in testicular cancer. Aim of this study was to evaluate the expression of Prok1 and ProkR1 in a series of testicular germ cell tumours (GCT).<...

Introduction: The presence of truncated variant of somatostatin receptors (SSTR) has been demonstrated in pituitary tumours. These variants seems act as dominant negative of SSTR and induce the resistance to SST analogue (SSTA) treatment. A variant of SSTR5, sst5TMD4, has been found to disrupt SST signalling in breast cancer cells. In present study, we assayed the expression of sst5TMD4 in two non-transformed epithelial prostate cell lines (EPC): EPN, derived from a normal sur...